PHARMACOLOGICAL BASIS OF ANTICANCER THERAPY: MODERN ASPECTS AND CLINICAL PROSPECTS

Arman Khozhayev; Zhanna Akimzhanova; Daniyar Abildinov; Lazzat Issa; Rumilyam Baudinova; Kundyz Tynyshtyk; Ayaulym Koshkin; Gauhar Nashen

Authors

Arman Khozhayev Oncologist, Professor, Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan
Zhanna Akimzhanova Oncologist-chemotherapist, Almaty Regional Multidisciplinary Clinic, Almaty, Kazakhstan
Daniyar Abildinov Oncologist-chemotherapist, Kostanay City Oncology Multidisciplinary Hospital, Kostanay, Kazakhstan
Lazzat Issa Oncologist-chemotherapist, Private Clinic Almaty, Almaty, Kazakhstan
Rumilyam Baudinova Resident clinical pharmacologist, Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan
Kundyz Tynyshtyk Resident clinical pharmacologist, Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan
Ayaulym Koshkin Resident clinical pharmacologist, Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan
Gauhar Nashen Resident clinical pharmacologist, Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan

Keywords:

clinical pharmacology, oncology, anticancer therapy, pharmacokinetics, pharmacodynamics, pharmacogenomics, biomarkers, personalized medicine, drug development, toxicity

Abstract

Cancer is a leading cause of death worldwide, making its treatment a priority in modern medicine. Advances in clinical pharmacology in oncology have significantly improved the efficacy and safety of anticancer therapy, ensuring a personalized approach to each patient. Studying the pharmacokinetics and pharmacodynamics of anticancer drugs, the mechanisms of drug interactions, and the characteristics of drug metabolism are key to optimizing treatment regimens and minimizing toxic effects. Modern clinical pharmacology in oncology aims to integrate data from pharmacogenomics and molecular biology, thereby promoting the development of personalized medicine and improving the quality of life of cancer patients

PHARMACOLOGICAL BASIS OF ANTICANCER THERAPY: MODERN ASPECTS AND CLINICAL PROSPECTS

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