INFLUENCE OF THE COMBINED ACTION OF CADMIUM CHLORIDE AND SODIUM NITRITE ON INDICATORS OF PHOSPHORUS-CALCIUM METABOLISM IN THE BLOOD OF RATS

Abstract

Cadmium chloride and sodium nitrite exhibit unidirectional toxic action that can lead to demineralization of bone tissue. Already on the first day after a ten-day exposure of animals to cadmium chloride and sodium nitrite, an increase in the concentration of both calcium and inorganic phosphate in plasma is observed, which obviously indicates a disturbance of the homeostatic mechanisms controlling the internal environment of the intoxicated animal's body. In the future, we plan to investigate the levels of calcitonin and parathyroid hormone, as well as vitamin D, which are regulators of the phosphorus-calcium exchange under the conditions of the combined influence of cadmium and nitrite salts.